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Friday, October 4 • 2:05pm - 2:25pm
AI in Chemistry- Development of MicroCycle 1.0: A New Tool for Drug Discovery

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Drug discovery requires developing a holistic understanding of the interaction between chemical and biological space. In the early phase, it is critical to develop this knowledge in a rapid and unbiased way, while benefiting from 150 years of drug hunting experience. We envisaged an iterative approach for project teams to navigate early drug discovery. Each iteration begins with a digital - human collaboration to select chemical starting points (scaffolds & BBs), leading to synthesis on a biologically relevant scale, followed by purification & characterization of these compounds, and testing in a range of integrated, automated and relevant assays. The process concludes with a machine learning based multi-parameter analysis of data in order to select next round of compounds. The first generation platform - MicroCycle 1.0 - has been developed and delivered in our Basel and Cambridge Labs. We look forward to sharing with you the story of platform development along with some key early results.

Speakers
avatar for Jonathon Grob

Jonathon Grob

Investigator, Novartis Institutes of Biomedical Research
I am a chemist who is passionate about leveraging my experience inMedicinal Chemistry & technology development to instigate a transformation towardautomation & digital enabled drug hunting. 18 years at Novartis. Worked at 3 sites inmy first 4 years. Currently working with a global... Read More →

Chairs

Friday October 4, 2019 2:05pm - 2:25pm
Theater Ballroom (5th Fl) - Courtyard Boston Downtown 275 Tremont Street, Boston, MA 02116